Effect of microRNA-143-3p-mediated CTNND1 on the biological function of lung cancer cells

Lung cancer poses a serious threat to human life with high incidence and miRNA is an important biomarker in tumors. This study aimed to explore the effect of miR-143-3p on the biological function of lung cancer cells and the underlying mechanism. Eighty-seven samples of lung cancer tissues and 81 samples of tumor-adjacent tissues from patients undergoing radical lung cancer surgery in our hospital were collected. The lung cancer cells and lung fibroblast cells (HFL-1) were purchased, and then miR-143-3p-mimics, miR-NC, si-CTNND1, and NC were transfected into A549 and PC-9 cells to establish cell models. MiR-143-3p and CTNND1 expression levels were measured by the qRTPCR, Bax, Bcl-2, and CTNND1 expression levels by the Western Blot (WB), and cell proliferation, invasion, and apoptosis by the MTT assay, Transwell assay, and flow cytometry. Dual luciferase report assay was used to determine the relationship between miR-143-3p and CTNND1. In this study, miR-143-3p was lowly expressed in lung cancer and CTNND1 was highly expressed in lung cancer. The overexpression of miR-143-3p inhibited cell proliferation and invasion, promoted cell apoptosis, significantly increased Bax protein expression, and decreased Bcl-2 protein expression. The inhibition of CTNND1 led to opposite biological characteristic in cells. The dual luciferase reporter assay demonstrated that miR-143-3p was a target region of CTNND1. Such results suggest that miR-143-3p can inhibit the proliferation and invasion of lung cancer cells by regulating the expression of CTNND1 and promote the apoptosis of lung cancer cells, sott is expected to be a potential target for lung cancer.     

含聚环氧乙烷链段梳形结构聚(异戊二烯-g-苯乙烯)的合成与表征

以聚苯乙烯(PS)大分子单体和异戊二烯为共聚单体,四氢呋喃为调节剂,正丁基锂为引发剂,三异丁基铝为助引发剂,脂肪族缩水甘油醚为官能化改性剂,采用一锅法经活性负离子共聚合制得以聚异戊二烯为主链、PS为规整侧链,且末端含星形聚环氧乙烷链段的极性化梳形聚(异戊二烯-g-苯乙烯-s-环氧乙烷)(PI-g-PS-s-PEO),利用凝胶渗透色谱仪、傅里叶变换红外光谱仪、差示扫描量热仪等对所制备的PI-g-PS-s-PEO进行了表征,并考察了PI-g-PS-s-PEO中聚环氧乙烷链段(PEO)质量分数(w_(PEO))的影响因素。结果表明,产物具有分子结构可设计、分子量分布窄等优点。此外,PS大分子单体分子量对w_(PEO)无影响,减小缩水甘油醚分子量、增加其用量及延长封端反应时间均可提高w_(PEO),且w_(PEO)在0.1%～1.8%可调。     

环保促进剂用量对丙烯酸酯橡胶/乙烯丙烯酸酯橡胶共混胶性能的影响

采用环保促进剂Vulcofac ACT 55与硫化剂Diak No 1组成硫化体系,研究了Vulcofac ACT 55用量对丙烯酸酯橡胶/乙烯丙烯酸酯橡胶共混胶性能的影响。结果表明,随着Vulcofac ACT 55用量的增加,共混胶的交联密度先增大后减小,焦烧时间逐渐缩短,硫化反应速率则逐渐增大;共混硫化胶的物理机械性能、耐热老化性能、耐ASTM No 1标准油性能和热稳定性先得到改善后又变差。差示扫描量热研究结果显示,Vulcofac ACT 55用量为2份(质量,下同)时共混硫化胶的耐IRM 903标准油性能最差、玻璃化转变温度最高。动态热机械分析结果显示,Vulcofac ACT 55用量超过2份后共混硫化胶的玻璃化转变温度逐渐降低,而用量不同共混硫化胶处于高弹态时的储能模量相近。     

聚氨酯/热塑性聚醚酯硫化胶动态硫化历程及结构与性能

使用高温开炼机制备了混炼型聚氨酯/热塑性聚醚酯动态硫化热塑性硫化胶(TPV),探索了TPV的动态硫化历程及结构与性能的关系。结果表明,不同的微观结构决定了TPV具有不同的物理性能;TPV动态硫化历程分为4个阶段,即动态硫化初始阶段、相反转开始阶段、相反转过渡阶段和相反转结束阶段;储能模量-温度曲线证明了相反转在14 min时结束;TPV的交联密度持续增大,而相容界厚度先减小后增大。     

改性氧化钛对羟乙基乙二胺水溶液解吸CO2的强化

羟乙基乙二胺（AEE）水溶液的CO₂循环吸收量高（1.2molCO₂/molAEE），吸收速度快，稳定性好，但解吸速度慢、解吸量少（0.8mol CO₂/mol AEE）是限制该技术广泛应用的主要原因。本文通过向AEE水溶液中添加质量分数为0.05%～0.20%的改性氧化钛（TiO₂-MWCNT和TiO₂-OH）强化AEE的解吸能力。CO₂循环吸收（40℃）-解吸（120℃）实验结果表明改性氧化钛的添加比氧化钛强化CO₂解吸效果更好，强化顺序为TiO₂-MWCNT＞TiO₂-OH；其对应的最大解吸速率分别为0.093L/min（质量分数0.15%）和0.083L/min（质量分数0.20%），相对于AEE水溶液，分别提高了32.9%和18.6%；其对应的最大解吸量分别为0.92molCO₂/molAEE（质量分数0.15%）和0.88molCO₂/molAEE（质量分数0.20%），分别提高了12.2%和9.7%；其对应的CO₂循环吸收量分别是0.95molCO₂/molAEE（质量分数0.15%）和0.89molCO₂/molAEE（质量分数0.15%），分别提高了18.75%和11.25%；5次循环吸收解吸实验结果表明改性氧化钛强化CO₂解吸效果稳定，具有较强的化学稳定性。对反应后的改性氧化钛进行XRD、BET、FTIR和SEM表征，结果表明改性氧化钛具有较强的结构稳定性。TiO₂-MWCNT和TiO₂-OH在促进有机胺溶液解吸CO₂方面具有一定的工业应用潜力。     

乳液原位加氢制备氢化丁腈橡胶的热氧老化性能及寿命（英文）

使用乳液原位加氢法选择性氢化丁腈胶乳制备了氢化丁腈橡胶(HNBR),对其热氧老化性能进行了研究。主要运用热重分析(TGA)并结合Flynn-WallOzawa法计算了热空气降解活化能,同时采用傅立叶变换衰减全反射红外光谱分析跟踪考察了HNBR在热氧老化过程中微观结构的变化。此外,通过对HNBR的物理机械性能的跟踪研究,计算了其老化温度系数及老化寿命与老化温度之间的关系,为HNBR在耐热领域中的应用提供理论依据。     

基于四元数理论的 ２ Ｕ ＰＳ-Ｐ Ｕ并联机构位置反解

介 绍 了 四 元 数 在 描 述 刚 体 位 置 和 方 位 中 的 应 用 ，并 简 要 描 述 了 ２ Ｕ ＰＳ-Ｐ Ｕ并 联 机 构 ，接 着 给 出 了利 用 四 元 数 计 算 ２ Ｕ ＰＳ-Ｐ Ｕ并 联 机 构 的 位 置 反 解 的 推 导 过 程 ，得 到 了 ２ Ｕ ＰＳ-Ｐ Ｕ并 联 机 构 的 位 置 反 解 公 式 ，最后 结 合Ｍ ＡＴ Ｌ Ａ Ｂ和 Ｓｏｌｉｄ Ｗ ｏｒｋｓ Ｍ ｏｔｉｏｎ 进 行 仿 真 分 析 ，仿 真 结 果 验 证 了 该 位 置 反 解 方 法 的 正 确 性 和 有 效 性 。     

Investigation on elemental mercury removal by cerium modified semi-coke

Coal-fired power plant is the largest anthropogenic mercury source. Active carbon injection technique has been widely used to control the mercury emissions. However, high operation cost limits its development and it is necessary to find other potential mercury sorbents. In this study, raw semi-coke and a series of novel cerium (Ce) modified semi-cokes were synthesized and utilized for removing elemental mercury (Hg⁰) from simulated flue gas. It is noteworthy that the efficiencies were tested without hydrogen chloride (HCl) in order to evaluate the sorbents efficacy for low-chlorine (Cl) coal. The results show that the modified sorbents exhibited the best performance at 150 °C. The performance of sorbent could be reinforced due to the existence of oxygen (O₂), nitric oxide (NO) and HCl. The adverse effect caused by sulfur dioxide (SO₂) reduced dramatically after Ce modification. The negative impact of ammonia (NH₃) on Hg⁰ removal in this study could be neglected owing to the tiny concentration of NH₃. Raw semi-coke provided sufficient carbon content, which is favorable to mercury adsorption. As Ce loading increased, the carbon structure changed and the crystal of cerium oxide was formed in the modified semi-coke. The mass fraction of cerium oxide on the sorbent was over 4.4% when the concentration of Ce modification solution was higher than 0.2 mol L⁻¹. The redox reaction activity and the oxygen storage ability of Ce³⁺/Ce⁴⁺ gave a huge boost to the performance of modified semi-coke. The addition of Ce also had an impact on the proportion of oxygen species.     

协同二酰亚胺催化剂制备氢化丁腈橡胶（英文）

采用维生素C、对苯二酚和茶多酚协同二酰亚胺对丁腈橡胶(NBR)分子链双键进行加氢,有效解决了NBR乳液二酰亚胺原位加氢过程中加氢程度低、凝胶含量高的问题。结果表明,采用维生素C、对苯二酚和茶多酚协同还原剂制备的氢化NBR(HNBR)的加氢程度明显提高,说明协同还原剂可参与双键加氢反应并起促进作用。与此同时,在NBR乳液加氢体系中引入协同还原剂有效降低了产物的凝胶含量。维生素C、对苯二酚和茶多酚均呈现一定的还原性和水溶性,可较好地溶解在NBR胶乳体系中,有效消除胶乳体系中的自由基,避免自由基之间的交联产生凝胶。HNBR经协同还原剂加氢后,热稳定性及低温柔韧性均有提高。     

Direct Z-scheme photocatalytic overall water splitting on two dimensional MoSe2/SnS2 heterojunction

The direct Z-scheme photocatalysts for overall water decomposition have aroused much concern on account of their strong redox ability and efficient separation of photogenerated electron-hole pairs. In the present work, we have constructed the two dimensional (2D) van der Waals (vdW) MoSe₂/SnS₂ heterojunction and investigated its electronical and optical properties by applying hybrid functional calculations. The calculated band structures have implied that the MoSe₂/SnS₂ heterostructure as a direct Z-scheme photocatalyst can make the best of visible light. The induced built-in electric field can effectively improve the separation efficiency of the photoinduced carriers. Moreover, compared with the MoSe₂ and SnS₂ monolayers, the absorption intensity of MoSe₂/SnS₂ heterojunction is reinforced in the visible light range. Therefore, MoSe₂/SnS₂ nanocomposite shows a bright application prospect as a direct Z-scheme visible-light-driven photocatalyst for overall water splitting.